Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
نویسندگان
چکیده
Colon cancer (CRC) is one of the most common types in world. In this study, effects Tarantula cubensis alcoholic extract (TCAE) and Capecitabine CRC were investigated. Wistar albino rats divided into eight groups with 12 animals each group: untreated healthy groups, treated TCAE or Capecitabine, both Capecitabine. Azoxymethane was used all groups. administered to relevant starting 15th week. All euthanized after 18 weeks, tissue samples collected. The mRNA levels Bcl–2, Bax, Cas–3 harvested tissues determined using real–time PCR histopathologically abnormal crypt foci (ACF) scores determined. It found that modulated decreased Bax/Bcl–2 expression rate CC group, but had opposite effect animals, which significantly reduced compared (P<0.05). addition, lower other a paradoxical observed No significant change (P>0.05). Importantly, single combined use ACF can be stated specifically modulate ratio cancer, therapeutic efficacy achieved at dose 40 mg·kg-1.
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ژورنال
عنوان ژورنال: Revista científica
سال: 2023
ISSN: ['2070-8246', '2224-5545']
DOI: https://doi.org/10.52973/rcfcv-e33254